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molecular genetics

In the Journals – Diapause adaptation in Drosophila melanogaster

An amino acid polymorphism in the couch potato gene forms the basis for climatic adaptation in Drosophila melanogaster Most organisms are faced with dealing with seasonal variations in environmental conditions.  As winter approaches, physiological changes need to be implemented: deciduous… Continue reading →

DmWRNexo is a 3'-5' exonuclease

We’ve had another paper on the WRN exonuclease homologue accepted for publication.  In it we demonstrate that DmWNexo is a 3′-5′ exonuclease, and describe a new EMS allele. Here’s the abstract: The premature human ageing Werner’s syndrome is caused by… Continue reading →

In the Journals – The origins of HIV

This week’s edition of Nature has a brief paper (doi:10.1038/nature07390) reporting on the identification of an HIV positive tissue sample collected in Leopoldville (now Kinshasa) in what was then the Belgian Congo, and now known as the Democratic Republic of… Continue reading →

In the Journals – Polytene Chromosomes and the Evolution of Drosophila

A. Bhutkar, S. W. Schaeffer, S. M. Russo, M. Xu, T. F. Smith, W. M. Gelbart (2008). Chromosomal Rearrangement Inferred From Comparisons of 12 Drosophila Genomes Genetics, 179 (3), 1657-1680 DOI: 10.1534/genetics.107.086108 Back when I was a carefree postdoc, one… Continue reading →

What the heck is a Placozoan, anyway?

I was intrigued by a brief news piece in the latest issue of Science to fall onto my desk (the 22nd August issue).  This concerns the recently published genome sequence of Trichoplax adhaerens, a peculiar animal in a phylum I’d… Continue reading →

In the Journals – Identifying host factors required for influenza virus replication.

Drosophila RNAi screen identifies host genes important for influenza virus replication. Linhui Hao, Akira Sakurai, Tokiko Watanabe, Ericka Sorensen, Chairul A. Nidom, Michael A. Newton, Paul Ahlquist & Yoshihiro Kawaoka  Nature 2008 454;890-893 doi:10.1038/nature07151 [Full Text – subscription required]; [pdf… Continue reading →

In the Journals – A New Genetics of Metazoan Mitochondria?

Manipulating the Metazoan Mitochondrial Genome with Targeted Restriction Enzymes Hong Xu, Steven Z. DeLuca, Patrick H. O’Farrell Science 25 July 2008:Vol. 321. no. 5888, pp. 575 – 577DOI: 10.1126/science.1160226 Abstract Full Text (subscription required) – HTML PDF Mitochondria are the… Continue reading →

The Aging Cell paper – update

The publishers seem to be making changes at the Aging Cell web pages.  This has meant that the paper is not presently available on open access, for which which Lynne and I paid a significant amount. In the meantime, I’ve… Continue reading →

More on the Press Releases

Both the Open University and Oxford University websites have their own versions of the press release.  Lynne had a TV interview with BBC Oxford yesterday, while I had a radio interview yesterday and another scheduled for tomorrow (broadcast for today… Continue reading →

A BBSRC Press Release

I had a visit from a BBSRC Press Office person on Wednesday 8th May.  (The BBSRC are the UK Research Council that fund my current research into ageing, using Drosophila as a model system) This was to record some video… Continue reading →

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