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In the Journals – Diapause adaptation in Drosophila melanogaster

An amino acid polymorphism in the couch potato gene forms the basis for climatic adaptation in Drosophila melanogaster Most organisms are faced with dealing with seasonal variations in environmental conditions.  As winter approaches, physiological changes need to be implemented: deciduous… Continue reading →

DmWRNexo is a 3'-5' exonuclease

We’ve had another paper on the WRN exonuclease homologue accepted for publication.  In it we demonstrate that DmWNexo is a 3′-5′ exonuclease, and describe a new EMS allele. Here’s the abstract: The premature human ageing Werner’s syndrome is caused by… Continue reading →

Calvin Bridges 1889-1938

Calvin Bridges is, with Alfred Sturtevant, one of my heroes of Drosophila genetics.  Among his achievements were the demonstration and confirmation of the chromsome theory of inheritance, and the establishment of the polytene chromosome maps (for more about polytene chromosomes,… Continue reading →

In the Journals – Polytene Chromosomes and the Evolution of Drosophila

A. Bhutkar, S. W. Schaeffer, S. M. Russo, M. Xu, T. F. Smith, W. M. Gelbart (2008). Chromosomal Rearrangement Inferred From Comparisons of 12 Drosophila Genomes Genetics, 179 (3), 1657-1680 DOI: 10.1534/genetics.107.086108 Back when I was a carefree postdoc, one… Continue reading →

In the Journals – Identifying host factors required for influenza virus replication.

Drosophila RNAi screen identifies host genes important for influenza virus replication. Linhui Hao, Akira Sakurai, Tokiko Watanabe, Ericka Sorensen, Chairul A. Nidom, Michael A. Newton, Paul Ahlquist & Yoshihiro Kawaoka  Nature 2008 454;890-893 doi:10.1038/nature07151 [Full Text – subscription required]; [pdf… Continue reading →

What are the Header images?

The header images are all related to Drosophila: Above: These are the giant polytene chromosomes found in a variety of tissues in Drosophila – these are from the salivary gland cells of the third instar larva.  Calvin Bridges (see picture… Continue reading →

FlyTree – Academic heritage of Drosophila research

Here’s an cool page showing academic pedigrees of Drosophila workers: FlyTree.  It’s interesting to see how few steps it takes to get back as far as T. H. Morgan!  For example, here’s where I fit in the grand scheme: Robert… Continue reading →

Classic paper – Meiotic mutants also affect mitosis

The utilization during mitotic cell division of loci controlling meiotic recombination and disjunction in Drosophila melanogaster. Bruce S. Baker, Adelaide T. C. Carpenter, and P. Ripoll  Genetics 1978 90: 531-578. [Abstract] [PDF] As a postdoc, I worked for several years… Continue reading →

The video press release from the BBSRC

Well, I have finally plucked up the courage to present a link to the video press release that the BBSRC issued on youtube: [video:http://www.youtube.com/watch?v=IGQwz2Wv9FU 425×344]

In the Journals – A New Genetics of Metazoan Mitochondria?

Manipulating the Metazoan Mitochondrial Genome with Targeted Restriction Enzymes Hong Xu, Steven Z. DeLuca, Patrick H. O’Farrell Science 25 July 2008:Vol. 321. no. 5888, pp. 575 – 577DOI: 10.1126/science.1160226 Abstract Full Text (subscription required) – HTML PDF Mitochondria are the… Continue reading →

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